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- Second Wind Dreams, Inc.
- Second Wind Fund
- Second Wind Lung Transplant
- Secondhand Hounds
- Secular Student Alliance
- Sedona Chamber Music Society Inc
- Sedona-Oak Creek Unified School District Educational Foundation, Inc.
- SEE International
- See Turtles
- Seed Consulting Group
- Seed of Hope Foundation
- Seed Tree Inc
- Seedlings Braille Books For Children
- Seedlings of Change
- SeedMoney
- Seeds for a Future
- Seeds For Hope Inc
- Seeds for the Heart Ministries
- Seeds in the Middle
- Seeds of Literacy
- Seeds of Love
- Seeds of Solidarity Education Center Inc
- Seeds to Sew International Inc.
- Seeing Eye, Inc.
- Seeing How Others Exist In Society
- SeekHealing
- Seeley Lake Community Foundation
- Seer Farms Inc
- Seicento Baroque Ensemble
- SEJA
- SEL4CA
- SELAH
- Selah Freedom
- Self Chec Inc
- Self Enhancement, Inc.
- Self Enquiry Life Fellowship
- Self Help Center
- Self Knowledge Base & Foundation
- Self Reliance Promoters' NGO
- Self Sustaining Communities
- Self-Help for the Elderly
- Self-Help International
- Self-Realization Fellowship Church
- Selfless Love Foundation Inc
- Semper Fi & America's Fund
- Semper K9 Assistance Dogs
- Semper4Veterans
- Sempervirens Fund
- Seneca Family of Agencies
- Senecorps Inc
- Senhoa
- Senior Alliance For Empowerment (SAFE)
- Senior Citizens Council of Clackamas County Inc
- Senior Connections, Inc.
- Senior Dog Rescue of Oregon
- Senior Friendship Centers Inc
- Senior Games
- Senior Services Of Van Buren County Inc
- Senior Volunteer Services
- Seniors First
- Seniors Personal Assistance Corporation
- SENIORS RESOURCE CENTER INC
- SENS Research Foundation
- Sensational Fun Inc
- Sensations Charitable Foundation Inc
- Sense International India
- Sentinels Of Freedom Scholarshipfoundation
- Sentry Living Solutions.
- Sepsis Alliance
- Sepsis Survivors Inc
- Sequoia Mental Health Services Inc
- Seraphic Mass Association Inc
- Serce Dla Psa
- Serenade Heights Inc
- Serendipity Equine Haven of Fort Worth
- Serendipity Wildlife Foundation
- Serenity Acres Horse Rescue
- SERENITY CHARITY CLUB
- Serenity Equine Rescue and Rehabilitation
- Serenity Horse Rescue, Inc.
- Serenity Saviors
- SERENITY TRAUMA FOUNDATION
- Serenity Veterans Village, Inc
- Serenitys Grace Inc
- SERES Global
- Sergeant York Patriotic Foundation
- Serious Fun Children's Network
- SERTOMA CENTRE INC
- SERUDS
- SERV International
- Servants 4 Him Inc
- Servants Heart Center Food Bank
- Servants Heart Haiti Mission
- Servants Inc
- Servants Of Christ International Inc
- ServantsOfpraise
- Serve and Return, Inc
- Serve Our Willing Warriors
- Serve The City Peninsula
- SERVE, Inc.