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- Southwest Autism Research and Resource Center
- Southwest Florida Symphony
- Southwest Key Programs Inc
- Southwest Missouri Office of Aging
- Southwest Veterans Business Resource Center
- Southwinds, Inc.
- Souzas Sanctuary
- Sovereign Hospitaller Order of St John of Jerusalem Inc
- SOWED Kenya (Social Welfare Development Programme)
- SOWHOPE
- Space Coast Feline Network Inc
- Space Coast Symphony Orchestra Inc
- Spandana Foundation
- Spark
- Sparrow Clubs USA
- Spartanburg Area Conservancy Inc
- Spay First!
- Spay Houston
- Spay n Save
- Spay Neuter Network
- Spay Panamas Animals Yes USA
- Spay-Neuter Assistance Program, Inc.
- Spay-Neuter Services of Indiana
- SPCA for Monterey County
- SPCA International
- SPCA of Franklin County
- SPCA Tampa Bay
- spcaLA
- SPEAK
- Speak Out Against Bullying, Inc
- Speak Up For Horses Inc
- SpeakeasyDC
- Special Angel Inc
- Special Equestrian Riding Therapy Inc
- Special Equestrians Inc.
- Special Forces Assn
- Special Horses
- Special Medical Response Team
- Special Olympics Massachusetts Inc
- Special Olympics Michigan Inc
- Special Olympics Southern California Inc
- Special Operations Warrior Foundation
- Special Populations Tennis Program Inc
- Special Spaces
- Special Surfers
- Spectordance
- Spectrum Charter School Inc
- Spectrum Designs Foundation Ltd.
- Speech and Language Development Center
- Speedway Angels
- Spendsmart Inc
- Spertus Institute for Jewish Learning and Leadership
- Sphoorti Foundation
- Spikenard Farm Honeybee Sanctuary
- Spina Bifida Association of America
- Spina Bifida Association of Western Pennsylvania
- Spirit Acres Farm Equine Rescue and Sanctuary
- Spirit Jump
- Spirit Key Inc
- Spirit Led Ministries
- Spirit of Blue Foundation
- Spirit of Sharing (SOS)
- Spirit Open Equestrian Program
- Spirit Rock Meditation Center
- Spirit Therapies
- Spirithorse Therapeutic Riding Center
- Spiritual Life Center Inc
- Spirituality For Kids International Inc
- Spoiled Acres Rescue Inc
- Spokane HOPE Hearing-Oral Program of Excellence
- Spondylitis Association of America
- Sporting Woman Community Fund
- Sportsgrants Inc
- Spotlight Kids Theatre Inc
- Spotlight Youth Theatre
- Spreading the Love of Jesus Ministry
- Spring Creek Horse Rescue
- Spring Mountain Benefit Corp
- Spring Reins of Life Inc.
- Spring Street CDC (SOAR, C.H.A.N.G.E. Fitness, Table of Hope)
- Springboard Enterprises
- Springboard Forward
- Springfield Rescue Mission, Inc.
- Springfield Victory Mission Inc
- Springs of Hope Kenya Inc
- Sprites Humane Education and Research Organization Inc.
- Sprout Inc
- SPUR
- SQ Foundation
- Square Care Ministries Inc.
- Square Foot Gardening Foundation
- Square Peg Foundation
- Squash Smarts Inc
- Sree Prayukti Seva Trust
- SSEP
- Ssubi Foundation aka Ssubi is Hope
- St Ann Center for Intergenerational Care, Inc
- St Annes Center Inc
- ST ANNES GUEST HOME
- St Augustine School Alumni International Inc
