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- Special Compass Inc
- Special Equestrian Riding Therapy Inc
- Special Equestrians Inc.
- Special Forces Assn
- Special Horses
- SPECIAL LEISURE SERVICES FOUNDATION (SLSF)
- Special Medical Response Team
- Special Needs Respite Inc
- Special Needs Services Of Ray County
- Special Needs Siblings Inc
- Special Olympics Connecticut Inc
- Special Olympics Massachusetts Inc
- Special Olympics Michigan Inc
- SPECIAL OLYMPICS NEW YORK INC
- Special Olympics Southern California Inc
- Special Olympics Texas Inc
- Special Operations Forces To School Of Medicine
- Special Operations Warrior Foundation
- Special Populations Tennis Program Inc
- Special Spaces, Inc .
- SPECIAL SPIRIT INC
- Special Surfers
- Specialized Needs Recreation Inc
- Specially Gifted Foundation
- Spectordance
- Spectrum Charter School Inc
- Spectrum Designs Foundation
- Spectrum School
- Sped Net Special Education Network Of Wilton Ltd
- Speech and Language Development Center
- Speedway Angels
- Spero f/k/a Blue Water Pregnancy Care Center
- Spertus Institute for Jewish Learning and Leadership
- Sphoorti Foundation
- Spikenard Farm Honeybee Sanctuary
- Spina Bifida Association of America
- Spina Bifida Association of Greater New England
- Spina Bifida Association of Western Pennsylvania
- Spina Bifida Kansas Organization
- Spinecore Foundation Inc
- SpineHope
- Spirit Acres Farm Equine Rescue and Sanctuary
- Spirit In Action
- Spirit Jump
- Spirit Key Inc
- Spirit Led Family
- Spirit of Blue Foundation
- Spirit of Dixie Horse Hayven Co
- Spirit Of Giving Network
- Spirit Of Hope Foundation Inc
- Spirit of Sharing (SOS)
- Spirit Open Equestrian Program
- Spirit Rock Meditation Center
- Spirit Therapies
- SpiritCare Ministry To Seniors
- Spirithorse Therapeutic Riding Center
- Spiritual Life Center Inc
- Splash Of Love From Home Inc
- Spoiled Acres Rescue Inc
- Spokane Hearing Oral Program of Excellence (HOPE)
- Spondylitis Association of America
- Spoofdawg To The Rescue
- Sporting Woman Community Fund
- Sportsgrants Inc
- SportsWorks Int'l Ngo, Inc.
- Spotlight Kids Theatre Inc
- Spotlight Youth Theatre
- Spots Last Stop Inc
- Spread The Cheer USA
- Spreading the Love of Jesus Ministry
- Spring Branch Rescue
- Spring Creek Horse Rescue
- Spring Mountain Benefit Corp
- Spring Reins of Life Inc.
- Spring Street CDC (SOAR, C.H.A.N.G.E. Fitness, Table of Hope)
- Springboard Enterprises
- Springboard Forward
- Springfield Rescue Mission (SRM)
- Springs of Hope Kenya Inc
- Sprites Humane Education and Research Organization Inc.
- Sprout Inc
- Sprout Therapeutic Riding And Education Center
- SPUR
- SQ Foundation
- Square Care Ministries Inc.
- Square Foot Gardening Foundation
- Square One For Youth
- Square Peg Foundation
- SQUARE UP FOR OTHERS INC
- SquashSmarts, Inc
- SquirrellyAF Wildlife Rescue
- Sree Prayukti Seva Trust
- SRGDRR
- Sri Karunamayi Institute of Vedic Studies and Meditation Center
- Ssamba Foundation
- SSEP
- SSP International, Inc.
- Ssubi Foundation aka Ssubi is Hope
- St Annes Center Inc
- ST ANNES GUEST HOME