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- SHRM FOUNDATION
- Shurruns House
- Shuzz Fund Inc.
- Shwachman Diamond Syndrome Foundation Inc
- Shwachman-Diamond Syndrome Alliance Inc
- Shy Wolf Sanctuary Education and Experience Center Inc
- ShyAnn's Hope
- Siamese Cats Rescue Center
- Sibling Connections, Inc.
- Sicilian Association Of Greater Boston Inc
- Sick Kids Need Involved People of New York Inc
- Sickle Cell Awareness Foundation Corp Int
- SIDDHARTHA SCHOOL PARTNERSHIP
- Side by Side Brain Injury Clubhouse
- Side by Side, Inc.
- SIDES (Sydney's Incredible Defeat of Ewings Sarcoma)
- SIENA FRANCIS HOUSE
- Siena Retreat Center Inc
- Sierra Club
- Sierra Club Foundation
- Sierra House
- Sierra Nevada Children's Museum AKA KidZone Museum
- Sierra Nevada Journeys
- Sierra Pacific Great Pyrenees Clu
- Sierra Repertory Theatre
- Sierra State Parks Foundation
- Sierra Vista Community Theatre Group Llc
- Sierra Wildlife Rescue
- Sight And Sound Care-Vision care for the music industry
- Sight Loss Services Inc
- Sights on Health, Inc.
- SIGN Fracture Care International
- Signature Gives Back Inc
- Signature Theatre Inc
- SIHANOUK HOSPITAL CENTER OF HOPE
- Sikh Research Institute
- Silent Sidekicks
- Silent Stars Foundation
- Silentwoods Collective Inc
- Silicon Andhra
- Silicon Valley Bicycle Coalition
- Silicon Valley Council Of Nonprofits
- Silicon Valley FACES
- Silicon Valley Independent Living Center
- SILICON VALLEY PET PROJECT
- Silicon Valley Shakespeare
- Silicon Valley Social Venture Fund
- Silicon Valley Urban Debate League
- Silk Road Rising
- Silk Screen Asian American Festival
- Silver Cloud Special Cat Services
- Silver Lining Riding Program
- Silver Ribbon Campaign to TRUST WOMEN with reproductive rights
- Silver Spring Village Inc
- SilverSource
- Silverstray Social
- Simcha Layeladim (Kids Vs. Cancer)
- Simi Valley Bulldogs Football & Cheer
- Simon's Heart
- SIMON'S SOUP KITCHEN
- Simone's Kids
- Simonton Cancer Counseling Center Charitable Trust
- Simplemath Foundation
- Simplicity Educational Services
- Simply Equal Education
- Simply Hygiene
- Simply Smiles Inc
- Simpson Housing Services, Inc.
- Sims-Fayola Foundation
- Sincerely Paul Feeding His Sheep
- Sincop8ed Noize Foundation
- Sing For Hope
- Sing For Your Seniors Inc
- Singing Sensations Youth Choir
- Singing Women of Texas (Southeast Chapter)
- Single Mom Strong, Inc.
- Single Mothers Outreach Inc
- Single Parent Advocate
- Single Parent Scholarship Fund Of Pulaski County
- Sink or Swim Philadelphia
- Sipping PositiviTEA
- SIRE, Inc.
- Sirenian International
- Siskiyou Community Food Bank
- Siskiyou Humane Society Inc
- Sistahs Surviving Breast Cancer
- Sistas Circle Inc
- Sistaz With Faith
- Sister 2 Sister Inc.
- SISTER PARISH INC
- Sister to Sister: The Women's Heart Health Foundation
- Sister-Corps
- Sister-To-Sister 2 Incorporated
- Sister2sister Virtuous Women Of Order Inc
- Sisterhood Against Sexual Assault
- Sisterhood Agenda
- Sisterhood For Good Inc
- Sisters 4 Sisters Inc
- Sisters 4 Sisters Network, Inc.
- SISTERS ACTION TEAM