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- Empart USA
- Empire Ranch Foundation
- Employment for Seniors Inc
- Employment Skills Center
- Empower 2 Play
- Empower and Connect
- Empower East
- Empower Energy Group Inc.
- Empower Illinois
- Empower Playgrounds Inc
- Empowered Community Services
- Empowered For Excellence Behavioral Health of Ohio
- Empowered Tutoring
- Empowered Women International
- Empowered Women of Faith & Purpose, Inc
- Empowering Children Bay Area
- Empowering Minds International Inc,
- Empowering Spirits Foundation, Inc.
- Empowering Women Worldwide Ministries Inc
- Empowerment International
- Empowerment Through Education and Exposure
- Empowerment Through Sports
- EmpowerSurvivors
- Empowher Enterprises Inc
- EMQ FamiliesFirst
- Enab Baladi
- Enable, Inc.
- Enacte Arts Inc
- ENC, Inc
- Encephalitis Global
- Enchanted
- Enchanted Closet, Inc.
- Enchanted Makeovers
- Encircle: LGBTQ Family & Youth Resource Center
- Encompass
- Encore Stage & Studio Inc
- enCourage Kids Foundation
- ENCOURAGEMENT INCORPORATED
- END HUNGER CONNECTICUT!, INC
- End Slavery Tennessee
- END STALKING IN AMERICA INC
- End Violence Against Women (EVAW) International
- Endangered Primate Foundation
- Endangered Species International
- Endangered Wolf Center
- Endeavors®
- Endo Forward Foundation
- Endometriosis Association, Inc.
- Endometriosis Research Center and Women's Hospital, Inc.
- Endorphin Project
- Endowment Fund – Meals On Wheels, Inc. of Tarrant County
- Enduring Hearts, Inc
- Energy and Sciences Academy Inc
- Energy Outreach Colorado
- Enfield Loaves and Fishes Inc.
- Engage Now Africa Inc
- Engaging Creative Minds
- EngenderHealth, Inc.
- English Empowerment Center (formerly Literacy Council of Northern Virginia)
- English River Outfitters Resort
- English Springer Rescue America Inc
- Enhancing Skills For Life
- Enkais Children
- Enlightened Kids Of The Future, Inc.
- Enlightened Warriors Boys Girls Of Virtue And Purpose
- Enrichment Audio Resource Services, Inc.
- Enrichment Circle Inc.
- Enrichment Works
- Enter Stage Left Theater, Inc.
- Enter Stage Right, Inc
- Enterprise for Youth
- Enterprising Latinas, Inc.
- Entertainment With A Mission Charity Inc
- Entito Africa Initiative, Kenya
- Entrepreneurs Scholarship Program
- Enventure
- Environment California Inc
- Environment for the Americas
- Environmental and Energy Study Institute (EESI)
- Environmental Defense Fund
- Environmental Fund for Arizona
- Environmental Law & Policy Center Of The Midwest
- Environmental Law Alliance Worldwide - ELAW
- Environmental League of Massachusetts
- Environmental Learning for Kids
- Environmental Support Center Inc
- Environmental Traveling Companions
- Environmental Volunteers, Inc.
- Environmental Working Group
- Envision Children
- Envision Minnesota
- Envision Mission Church
- Envision Performing Arts Inc
- ENVISION PROVEN SUCCESS
- ENVISION THERAPEUTIC HORSEMANSHIP
- Enyi Md Foundation Inc
- EOTO World
- Ephraims House
- Epic Experience
- EPILEPSY Association OF NORTH CAROLINA