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- Orphans Heroes
- Orphans Tree Inc
- Orphans World Wide Inc
- Orphans' Future Foundation Ukraine
- Orpheus Male Chorus Of Phoenix
- Ort America Inc
- Osa Conservation
- Oscar Litwak Foundation
- Oscar Mike Foundation
- OSEI-KUSI FOUNDATION (OKF)
- Oshkosh Area Humane Society Inc
- Osprey Village, Inc.
- Ossining Volunteer Ambulance Corps Inc
- OSSO
- Ostego Bay Foundation Inc
- Other Options, Inc.
- Other Side Intercultural Theatre Inc
- Others First Inc
- OTTUMWA AREA COMMUNITY CHORUS (adult chorus and children's chorus)
- Ouaganet, Inc.
- Our Brothers' Keepers Of Southern Illinois
- Our Children International Corp
- Our Children's Trust
- Our Childrens House Inc
- Our City Beautiful Inc
- Our City Forest
- Our Community LA
- Our Companions Domestic Animal Sanctuary Inc
- Our Daily Bread Food Pantry
- Our English Setter Rescue
- Our Family Coalition
- Our Family In Africa
- Our Family Orphan Communities, Inc.
- Our Farm Sanctuary
- OUR FRIENDS PLACE
- Our Health Inc
- OUR HEARTS TO YOUR SOLES
- Our Home Transitional
- Our House, Inc.
- Our Kitchen Table
- Our Lady's Inn
- Our Military Kids, Inc.
- Our Mims Retirement Haven, Inc.
- Our Nawakwa
- Our Place in New York, Inc.
- Our Rescue
- Our Santa Fe River Inc.
- Our Wave Inc
- OurJewishCommunity.org
- OUT ALLIANCE aka GAY ALLIANCE OF THE GENESEE VALLEY INC
- Out Of The Box Boxer Rescue Inc
- Out Of The Woodworks Productions
- Out on a Limb Dance Theater Company and School
- Out Youth
- Outcast Rescue
- Outdoor Discovery Center - Macatawa Greenway
- Outdoor Immersion
- Outdoor Promise
- Outdoors Tomorrow Foundation
- Outer Banks Dare Challenge
- Outer Banks Wildlife Shelter Inc
- Outfest
- OUTMemphis: The LGBTQ Center for the Mid-South
- Outreach For Animals Inc
- Outreach Inc
- Outreach Inc
- Outreach International
- Outreach Resource Center
- Outreach Teen & Family Services
- Outreach360
- Outreached Arms
- Outright Vermont
- Outsiders Farm & Sanctuary, Inc
- Outta The Cage
- Ov-10 Bronco Association Inc dba Fort Worth Aviation Museum
- Oval Community Youth Program Inc
- Ovarcome
- Ovarian Awareness of Kentucky
- Ovarian Cancer Connection
- Ovarian Cancer National Alliance
- Ovarian Cancer Research Fund, Inc.
- Ovarian Cancer Symptom Awareness Organization
- Over The Rainbow Butterfly Garden Inc
- Overcomers Daughters of the King of Kings
- Overlook Foundation
- Overlooked Creations Inc
- Overseas Fishing
- Overseas Instruction In Counseling Inc
- Owasso Foundation
- OwieBowWowie and Friends Foundation
- Owl Hollow Farm
- Owners in Honor
- Oxalosis and Hyperoxaluria Foundation
- Oxfam America
- Oxlajuj B'atz // Thirteen Threads // Trece Hilos
- Oyster River Ecology
- Oyster River Womenade
- Ozark Homeward Bound
- Ozark Pride Inc
- Ozaukee Family Services