Jacob's Cure, Inc. Overview
Jacob’s Cure is a 501c3, non-profit foundation that was created in September 2000. Jordana Holovach is the Founder and Director of Jacob’s Cure. She created the foundation because of her passion to save the life of her son, Jacob, who is afflicted with Canavan disease, a fatal genetic brain disorder. The sole mission of Jacob’s Cure is to fund research in Canavan disease that aims to cure thousands of children dying of Canavan disease today. Jacob’s Cure allocates monies raised to research, this is made possible due to volunteer staff and minimal overhead. Areas of research include gene-therapy, stem cell transplantation, pharmacological approaches and basic science in understanding the pathways of the disease. Because Canavan is a rare disorder, federal funding is scarce. It is through the efforts of Jacob’s Cure and the philanthropy of others that enables Canavan research to continue and a cure for Canavan a hopeful reality.
To date, Jacob’s Cure has funded two gene-therapy trials and is currently funding research towards a phase 1 stem-cell clinical trial aimed for 2011. Research efforts to date have slowed down and in some cases halted the progression of the disease in most of the children who received gene-therapy and have begun the recommended pharmacological regimen.
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Jacobs Cure is an amazing organization. It is an incredible resource for families affected by Canavan Disease. It allow families, like ourselves, the opportunity to share and learn from each other. Because of Jordana's strength and tireless efforts, she has helped raise awareness and bring ... more »
Because of Jacobs cures dedication to the fight against Canavan disease, there is hope. Hope that one day there will be a cure for this devastating illness that has claimed the life of my daughter, Amber, and threatens the lives of my other daughters, Ariel and Kaydi. There are no words that can ... more »
To the board members of Jacob’s Cure, we, as parents, are grateful for your time, your talents, and your gifts. For your unselfish devotion to the work that has made Jacob’s Cure a force that has enabled treatments to be developed when there was none, to give hope where there was none, and ... more »