My Nonprofit Reviews
Review for Go4thegoal Foundation, Pennsauken, NJ, USA
As a pediatric oncologist and cancer biologist, I am dedicated to identifying the genetic drivers of childhood cancers and revealing the function of these genes. Knowledge about cancer causing genes including their normal roles in development can help us find new therapeutics that are targeted and personalized. Go4thegoal has supported my research investigating the developmental and cancer-related functions of a novel cancer gene called AF1q. We have found this gene to drive tumor formation in neuroblastoma, a terrible malignancy of childhood. We have discovered that this gene prevents cell aging, also called senescence, which may be one of the reasons why it promotes cancer cell survival. With funds from Go4thegoal we have also created a mouse lacking AF1q, and the fact that it survives shows that it may be possible to target this gene therapeutically. Thanks to Go4thegoal, this critical research is now moving forward! Thank you so much!