Mission: The Sanford-Burnham Medical Research Institute conducts world-class collaborative research dedicated to finding cures for human disease, improving quality of life, and thus creating a legacy for its employees, partners, donors, and community. With operations in California and Florida, Sanford-Burnham is one of the fastest growing research institutes in the country. Sanford-Burnham is home to five research centers: a Cancer Center, the Del E. Webb Neuroscience, an Aging and Stem Cell Research Center, an Infectious and Inflammatory Disease Center, a Diabetes and Obesity Research Center, and the Sanford Children’s Health Research Center. The Cancer Center has been supported by the National Cancer Institute (NCI) since 1981. It is one of only 7 NCI-designated basic science cancer centers in the country. The Del E. Webb Neuroscience, Aging and Stem Cell Research Center was established in 1999 with the aim to develop novel strategies for either protecting existing cells or replacing cells lost due to disease. The Infectious and Inflammatory Disease Center was founded in 2004 to address the global population's increasing vulnerability to emerging pathogens and to counter threats of deadly diseases intentionally introduced by bioterrorists. The center also seeks to discover new ways to treat chronic inflammatory diseases, some of which are linked to dysfunctional host responses to pathogens. The Diabetes and Obesity Research Center is headquartered at Lake Nona in Orlando, Florida. Research programs related to diabetes, obesity, metabolism and heart disease are being developed. The Sanford Children’s Health Research Center works in collaboration with Sanford Health of Sioux Falls, South Dakota. Its aim is to combine collaborative scientific talent with state-of-the-art technology to conquer childhood diseases. The Institute ranks among the top 4 institutions nationally for NIH grant funding and among the top 25 organizations worldwide for its research impact. Sanford-Burnham uses a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, infectious and inflammatory and childhood diseases. The Institute is known for its world-class capabilities in stem cell research and drug discovery technologies.