Goodwill Industries is the best non profit I know of. They provide work opportunties, job training and support services for people with disabilities or other employment barriers. Last year they provided employment, job training, job placement and/or case management services to over 5,800 individuals with disabilities or other employment barriers.
This is a Non Profit Organization that actually provides life changing assistance!
They also generated an ecomonmic impact in the community of more than $87 million as a result of their business operations and the wages earned by those who became employed in a job with Goodwill's assistance! I love Goodwill.