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Nonprofit Overview

Causes: Birth Defects & Genetic Diseases, Birth Defects & Genetic Diseases Research, Health, Medical Research, Pediatrics Research

Mission: Jacob’s Cure is a 501c3, non-profit foundation that was created in September 2000. Jordana Holovach is the Founder and Director of Jacob’s Cure. She created the foundation because of her passion to save the life of her son, Jacob, who is afflicted with Canavan disease, a fatal genetic brain disorder. The sole mission of Jacob’s Cure is to fund research in Canavan disease that aims to cure thousands of children dying of Canavan disease today. Jacob’s Cure allocates monies raised to research, this is made possible due to volunteer staff and minimal overhead. Areas of research include gene-therapy, stem cell transplantation, pharmacological approaches and basic science in understanding the pathways of the disease. Because Canavan is a rare disorder, federal funding is scarce. It is through the efforts of Jacob’s Cure and the philanthropy of others that enables Canavan research to continue and a cure for Canavan a hopeful reality.

Results: To date, Jacob’s Cure has funded two gene-therapy trials and is currently funding research towards a phase 1 stem-cell clinical trial aimed for 2011. Research efforts to date have slowed down and in some cases halted the progression of the disease in most of the children who received gene-therapy and have begun the recommended pharmacological regimen.

Programs: University of medicine & dentristry of new jersey $49,500 umass medical school $100,000 heartbeat lifesharing $250

Community Stories

5 Stories from Volunteers, Donors & Supporters

1

Volunteer

Rating: 4

Jacobs Cure is an amazing organization. It is an incredible resource for families affected by Canavan Disease. It allow families, like ourselves, the opportunity to share and learn from each other. Because of Jordana's strength and tireless efforts, she has helped raise awareness and bring research to the forefront of Canavan Disease. Jordana is an inspiration to all and has provided hope for all Canavan familes.

1

Volunteer

Rating: 5

Jacob's Cure is an organization that is not only dedicated to its cause but determined to find a cure and stop at nothing. I have known Jordana for many years and have traveled with her many times on behalf of Jacob's Cure and have seen her 'in action.' She is my inspiration and her team of volunteers and supporters couldn't be stronger.

5

Volunteer

Rating: 5

From seeing Jacob's Cure start from the very beginning to what it is now, i have seen an empire grow. Jordana has shown to everyone what sacrifice is all about. She went out and educated the public about this rare disorder. Jordana's true compassion and willingness for her child makes her a role model for everyone.

10

Volunteer

Rating: 5

I have had the privledge of working closely with Jordana Holovach as I cared for Jacob for over five years as his nurse. I watched Jacob's Cure from it's inception, take it's first baby steps. This organization has never been just about a Mother and her unending quest to save the life of her child, but about all the families having to face the realities of this disease. This extraordinary woman and this organization has helped so many by funding research and education so that families faced with this devastating diagnosis no longer have to face this alone.

10

Volunteer

Rating: 5

Jordana Holovach has dedicated her life to saving the life of her son Jacob and lives of millions of others. I have worked side by side with Jordana and other members of the organization and can tell you first hand how extraordinary this charity is. Jacob's Cure educates and funds research in very successful and unique ways. Whether through their last Gala event or advertisements on Taxi TV or through the Helen Ficalora "smile" charm or the annual Casino night/Bowling event, Jacob's Cure, is always looking for new ways to spread awareness and raise funds and make sure family and friends of Jacob's Cure have fun in the process.